Anti-Ly-49A antibodies, mouse

Anti-Ly-49A antibodies, mouse

Clone: A1 | Dilution: 1:10
Clone A1 recognizes Ly-49A, an inhibitory cell surface receptor belonging to the Ly-49 receptor family. Ly-49A is a 44 kDa type II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Expression of Ly-49A is found on subset of NK and NK-T cells. Ly-49 family members are both activating and inhibitory receptors and are mainly receptors for MHC class I molecules. Ly-49A interacts strongly with MHC class Ia molecules such as H-2D
d
, H-2D
k
and weakly with H-2D
b
. An inhibitory signal is delivered by Ly-49A engagement via the phosphorylation of immunoreceptor tyrosine based inhibition motif (ITIM) and recruitment of phosphatases SHP-1 and SHP-2. Recognition of cognate ligand bearing cells leads to inhibition of cytotoxic killing of cells by NK cells.

Alternative names

Klra1, A1, CH29-493D4.3, Klra22, Ly49v

Technical specifications

  • Antigen: Ly-49A
  • Clone: A1
  • Isotype: mouse IgG2aκ
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: Klra1, A1, CH29-493D4.3, Klra22, Ly49v
  • Entrez Gene ID: 16627
  • Molecular mass of antigen [kDa]: 30
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Chung, D. H. et al. (2000) Mapping the ligand of the NK inhibitory receptor Ly49A on living cells. J. Immunol. 165: 6922-6932
    2. Zimmer, J. et al. (2001)
      H-2D ligand expression by Ly49A
      +
      natural killer (NK) cells precludes ligand uptake from environmental cells: Implications for NK cell function.
      J. Exp. Med. 194(10): 1531-1539
    3. Daws, M. R. et al. (1999) H-2Dd engagement of Ly49A leads directly to Ly49A phosphorylation and recruitment of SHP1. Immunology 97(4): 656-664
Product options: 12
9 µg in 300 µL (1)
USD 20.00
30 µg in 1 mL (1)
USD 45.00
9 µg in 300 µL (1)
USD 36.00
30 µg in 1 mL (1)
USD 50.00
9 µg in 300 µL (1)
USD 55.00
30 µg in 1 mL (1)
USD 75.00
9 µg in 300 µL (1)
USD 47.00
30 µg in 1 mL (1)
USD 136.00
9 µg in 300 µL (1)
USD 47.00
30 µg in 1 mL (1)
USD 136.00
9 µg in 300 µL (1)
USD 25.00
30 µg in 1 mL (1)
USD 50.00

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