Anti-KLRG1 antibodies, human

Anti-KLRG1 antibodies, human

Clone: REA261 | Dilution: 1:50
Clone REA261 recognizes the killer cell lectin-like receptor subfamily G member 1 (KLRG1) antigen, a transmembrane protein, which is also known as C-type lectin domain family 15 member A (CLEC15A) or ITIM-containing receptor MAFA-L. KLRG1 is expressed by basophils, CD4 and CD8 T cells that exhibit a memory cell phenotype, and by a large proportion of peripheral blood NK cells. Expression of KLRG1 by virus-specific CD8
+
T cells is induced by repetitive antigen stimulation and it differs in chronic versus resolved viral infections. T cells expressing KLRG1 exhibit a poor proliferation potential, while their ability to secrete gamma interferon is preserved. Thus, KLRG1 is a convenient marker for early T cell–differentiation.
Additional information: Clone REA261 displays negligible binding to Fc receptors.

Alternative names

Killer cell lectin-like receptor subfamily G member 1, CLEC15A, MAFA, MAFA-2F1, MAFA-L, 2F1

Technical specifications

  • Antigen: KLRG1
  • Clone: REA261
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Killer cell lectin-like receptor subfamily G member 1, CLEC15A, MAFA, MAFA-2F1, MAFA-L, 2F1
  • Entrez Gene ID: 10219
  • Molecular mass of antigen [kDa]: 22
  • Distribution of antigen: basophils, T cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, FITC, PE, PE-Vio615, PE-Vio770, APC-Vio770, Biotin, VioBlue
  • Selected references

    1. Voehringer, D. et al. (2002) Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1). Blood 100: 3698-3702
    2. Thimme, R. et al. (2005) Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. J. Virol. 79: 12112-12116
    3. Butcher, S. et al. (1998) MAFA-L, an ITIM-containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK cells. Eur. J. Immunol. 28(11): 3755-3762
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