Anti-Integrin α9β1 antibodies, human

Anti-Integrin α9β1 antibodies, human

Clone: REA483 | Dilution: 1:11
Clone REA483 recognizes the human integrin α9β1 antigen, a single-pass type I membrane protein which is also known as integrin alpha-RLC. Integrins are heterodimeric glycoprotein receptors and exist as non-covalently bound α and β subunits. The integrin α9β1 binds a number of extracellular matrix components like VCAM1, cytotactin, and osteopontin to mediate cell adhesion, migration, and tissue invasion. Although widely expressed in a variety of normal human cells including endothelium, different types of muscle cells, hepatocytes, and in the hematopoietic system, it is also expressed in cancer cells. Expression of integrin α9β1 in human cancers appears to correlate with higher grade tumors.
Additional information: Clone REA483 displays negligible binding to Fc receptors.

Alternative names

ITGA9B1, ITGA9, ITGA-RLC, ITGB1

Technical specifications

  • Antigen: Integrin α9β1
  • Clone: REA483
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ITGA9B1, ITGA9, ITGA-RLC, ITGB1
  • Entrez Gene ID: 3680, 3688
  • Molecular mass of antigen [kDa]: 198
  • Cross-reactivity: guinea pig
  • Distribution of antigen: monocytes, granulocytes, neutrophils, liver, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, Biotin
  • Selected references

    1. Kanayama, M. et al. (2011) α9β1 integrin-mediated signaling serves as an intrinsic regulator of pathogenic Tʜ17 cell generation. J. Immunol. 187(11): 1271-1281
    2. Gupta, S. K. et al. (2013) Integrin α9β1 promotes malignant tumor growth and metastasis by potentiating epithelial-mesenchymal transition. Oncogene 32(2): 141-150
    3. Ota, D. et al. (2014) Tumor-α9β1 integrin-mediated signaling induces breast cancer growth and lymphatic metastasis via the recruitment of cancer-associated fibroblasts. J. Mol. Med. 92(12): 1271-1281
Product options: 6
for 30
tests
(1)
USD 138.00
for 100
tests
(1)
USD 345.00
for 30
tests
(1)
USD 104.00
for 100
tests
(1)
USD 272.00
for 30
tests
(1)
USD 86.00
for 100
tests
(1)
USD 232.00

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