Anti-IL-12 (p35/p70) antibodies, human

Anti-IL-12 (p35/p70) antibodies, human

Clone: REA121 | Dilution: 1:10
Interleukin-12 (IL-12) is a 70–75 kDa heterodimeric cytokine composed of a 40 kDa heavy chain and a 35 kDa light chain. It is produced mainly by monocytes and macrophages as well as dendritic cells, primarily in response to stimulation with bacterial or viral antigens. IL-12 has also been described to be produced by non-hematopoietic cells such as keratinocytes and epidermoid carcinomas. IL-12 displays various effects on both NK and T cells, playing an essential role in the interaction between innate and adaptive immunity: It induces the production of IFN-γ alone or in synergy with IL-2, is a co-stimulator of both NK and T cell proliferation, and enhances cytolytic activity of both cell types. Moreover, IL-12 promotes the development of T helper 1 (Tʜ1)-specific immune responses by promoting the differentiation of CD4
+
cells towards a Tʜ1 phenotype while inhibiting the production of Tʜ2 cells. The antibody clone REA121 reacts with the p35 kDa chain and the p70 kDa heterodimer of human IL-12, but not with IL-12 p40. It recognizes the same epitope as clone B-T21.
Additional information: Clone REA121 displays negligible binding to Fc receptors.

Alternative names

IL12A, CLMF, IL-12A, NFSK, NKSF1, P35

Technical specifications

  • Antigen: IL-12 (p35/p70)
  • Clone: REA121
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: IL12A, CLMF, IL-12A, NFSK, NKSF1, P35
  • Entrez Gene ID: 3592
  • Molecular mass of antigen [kDa]: 22
  • Distribution of antigen: monocytes, macrophages, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Trinchieri, G. et al. (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3(2): 133-146
    2. D´Andrea, A. et al. (1992) Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176: 1387-1398
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