Anti-IgE antibodies, human

Anti-IgE antibodies, human

Clone: REA1049 | Dilution: 1:50
Clone REA1049 recognizes the IgE isotype of human immunoglobulins. IgE is the shortest-lived immunoglobulin with a half-life of two days in serum. IgE plays an important role in allergy. It is especially associated with type 1 hypersensitivity, where IgE shows high-affinity binding to Fc receptors expressed on the surface of mast cells. Antigen binding to Fc receptor–bound IgE upon re-exposure to specific allergens results in degranulation and the release of a variety of mediators, such as histamine and cytokines.
IgE has two main receptors: the high-affinity receptor FcεRI, which is expressed only on mast cells and basophils, and the low-affinity receptor FcεRII (CD23), which is expressed on B cells.
Additional information: Clone REA1049 displays negligible binding to Fc receptors.

Technical specifications

  • Antigen: IgE
  • Clone: REA1049
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Entrez Gene ID: 3497
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: B cells, basophils, mast cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, PerCP-Vio700, VioBright 515, Biotin
Product options: 20
for 30
tests
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USD 82.00
for 100
tests
(1)
USD 242.00
for 30
tests
(1)
USD 104.00
for 100
tests
(1)
USD 278.00
for 30
tests
(1)
USD 124.00
for 100
tests
(1)
USD 288.00
for 30
tests
(1)
USD 130.00
for 100
tests
(1)
USD 315.00
for 30
tests
(1)
USD 162.00
for 100
tests
(1)
USD 345.00
for 30
tests
(1)
USD 142.00
for 100
tests
(1)
USD 305.00
for 30
tests
(1)
USD 148.00
for 100
tests
(1)
USD 320.00
for 30
tests
(1)
USD 138.00
for 100
tests
(1)
USD 325.00
for 30
tests
(1)
USD 166.00
for 100
tests
(1)
USD 415.00
for 30
tests
(1)
USD 82.00
for 100
tests
(1)
USD 242.00

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