Anti-IFNAR2 antibodies, human

Anti-IFNAR2 antibodies, human

Clone: REA124 | Dilution: 1:11
Clone REA124 recognizes the human interferon α/β receptor 2 (IFNAR2) antigen, a 100 kDa single-pass type I membrane protein that forms one of the two chains of a receptor for the type I interferons IFN-α, IFN-β, and IFN-ω. These interferons are a group of structurally and functionally related proteins, induced by viruses or double-stranded RNA and defined by their ability to establish an antiviral state in cells. IFNAR2 is expressed on most lymphocytes, monocytes, and granulocytes, although IFNAR2 expression is higher on monocytes and granulocytes than on lymphocytes. It is involved in IFN-mediated STAT1, STAT2, and STAT3 activation. The alternatively spliced isoform of IFNAR2 is a potent inhibitor of type I IFN receptor activity.
Additional information: Clone REA124 displays negligible binding to Fc receptors.

Alternative names

Interferon α/β receptor 2 (IFN-R-2, IFN-α binding protein, IFN-α/β receptor 2), IFN-R, IFN-alpha-REC, IFNABR, IFNARB

Technical specifications

  • Antigen: IFNAR2
  • Clone: REA124
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Interferon α/β receptor 2 (IFN-R-2, IFN-α binding protein, IFN-α/β receptor 2), IFN-R, IFN-alpha-REC, IFNABR, IFNARB
  • Entrez Gene ID: 3455
  • Molecular mass of antigen [kDa]: 54,8
  • Distribution of antigen: lymphocytes, monocytes, granulocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Constantinescu, S. N. et al. (1995) Expression and signaling specificity of the IFNAR chain of the type I interferon receptor complex. Proc. Natl. Acad. Sci. U.S.A. 92(23): 10487-10491
    2. Novick, D. et al. (1995) Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor. J. Leukoc. Biol. 57(5): 712-718
    3. Novick, D. et al. (1994) The human interferon alpha/beta receptor: characterization and molecular cloning. Cell 77(3): 391-400
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