Anti-HLA Class I B8 antibodies, human

Anti-HLA Class I B8 antibodies, human

Clone: REA145 | Dilution: 1:50
Clone REA145 recognizes HLA B8, a class I human leukocyte antigen (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, of which one comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells.
Additional information: Clone REA145 displays negligible binding to Fc receptors.

Alternative names

HLA-B, AS, SPDA1

Technical specifications

  • Antigen: HLA Class I B8
  • Clone: REA145
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: HLA-B, AS, SPDA1
  • Entrez Gene ID: 3106
  • Molecular mass of antigen [kDa]: 38
  • Distribution of antigen: B cells, dendritic cells, endothelial cells, granulocytes, T cells, macrophages
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE
  • Selected references

    1. Jahnsen, F. L. et al. (2018) Transcriptional and functional profiling defines human small intestinal macrophage subsets. J. Exp. Med. 215(2): 441-458
    2. Hewitt, E. W. et al. (2003) The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology 110(2): 163-169
    3. Edvardsen, K. et al. (2016) Analysis of cellular and humoral immune responses against cytomegalovirus in patients with autoimmune Addison's disease. J. Transl. Med. 14: 68
Product options: 4
for 30
tests
(1)
USD 82.00
for 100
tests
(1)
USD 242.00
for 30
tests
(1)
USD 104.00
for 100
tests
(1)
USD 278.00

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