Anti-HLA-B12 antibodies, human

Anti-HLA-B12 antibodies, human

Clone: REA138 | Dilution: 1:11
Clone REA138 recognizes HLA B12, a class I human leukocyte antigen (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, of which one comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells.
Additional information: Clone REA138 displays negligible binding to Fc receptors.

Alternative names

HLA-B, AS, SPDA1

Technical specifications

  • Antigen: HLA-B12
  • Clone: REA138
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: HLA-B, AS, SPDA1
  • Entrez Gene ID: 3106
  • Distribution of antigen: B cells, dendritic cells, endothelial cells, granulocytes, leukocytes, macrophages, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Hewitt, E. W. et al. (2003) The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology 110(2): 163-169
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