Anti-Helios antibodies, human and mouse

Anti-Helios antibodies, human and mouse

Clone: 22F6 | Dilution: 1:11
The monoclonal antibody 22F6 recognizes mouse and human Helios, which is a zinc-finger transcription factor of the Ikaros family. As well as Ikaros and Aiolos Helios functions as an important regulator of lymphoid development and differentiation and is involved in the control of gene expression. Helios is found on the earliest haematopoietic sites of the embryo, in adult haemopoietic stem cells and on regulatory T cells.

Alternative names

IKZF2, ANF1A2, ZNF1A2, ZNFN1A2

Technical specifications

  • Antigen: Helios
  • Clone: 22F6
  • Isotype: hamster IgG
  • Alternative names of antigen: IKZF2, ANF1A2, ZNF1A2, ZNFN1A2
  • Entrez Gene ID: 22807
  • Molecular mass of antigen [kDa]: 60
  • Cross-reactivity: rat
  • Distribution of antigen: T cells, hematopoietic stem cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Rebollo, A. et al. (2003) Ikaros, Aiolos and Helios: Transcription regulators and lymphoid malignancies. Immunol. Cell Biol. 81: 171-175
    2. Kelley, C. M. et al. (1998) Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. Curr. Biol. 8(9): 508-515
    3. Gottschalk, R. A. et al. (2012)
      Expression of Helios in peripherally induced Foxp3
      +
      regulatory T cells.
      J. Immunol. 188: 976-980
    4. Thornton, A. M. et al. (2010)
      Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3
      +
      T regulatory cells.
      Curr. Biol. 184: 3433-3441
Product options: 6
for 30
tests
(1)
USD 82.00
for 100
tests
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USD 232.00
for 30
tests
(1)
USD 97.00
for 100
tests
(1)
USD 272.00
for 30
tests
(1)
USD 124.00
for 100
tests
(1)
USD 288.00

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