Anti-ErbB-2 (CD340) antibodies, human

Anti-ErbB-2 (CD340) antibodies, human

Clone: REA1232 | Dilution: 1:50
Clone REA1232 recognizes the human receptor tyrosine-protein kinase ErbB-2 antigen, a Single-pass type I membrane protein which is also known as CD340, human epidermal growth factor receptor 2 (Her2) or proto-oncogene Neu. ErbB-2 is a member of the epidermal growth factor receptor family. The ErbB family is composed of four plasma membrane-bound receptor tyrosine kinases. All four contain an extracellular ligand binding domain, a transmembrane domain, and an intracellular domain that can interact with a multitude of signaling molecules and exhibit both ligand-dependent and ligand-independent activity. ErbB-2 can heterodimerise with any of the other three receptors and is considered to be the preferred dimerisation partner of the other ErbB receptors. Dimerisation results in the autophosphorylation of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways. ErbB-2 has been shown to be involved in embryonic development and cancer progression. Amplification or overexpression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of cancer. In recent years the protein has become an important biomarker and target of therapy for approx. 30% of breast cancer patients.
Additional information: Clone REA1232 displays negligible binding to Fc receptors.

Alternative names

p185erbB2, HER2, MLN19, NEU, NGL, HER2/neu

Technical specifications

  • Antigen: ErbB-2 (CD340)
  • Clone: REA1232
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: p185erbB2, HER2, MLN19, NEU, NGL, HER2/neu
  • Entrez Gene ID: 2064
  • Molecular mass of antigen [kDa]: 136
  • Distribution of antigen: cancer cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio615, PE-Vio770, APC-Vio770, VioBright 515, Biotin, PE, APC
  • Selected references

    1. Yamamoto, T. et al. (1986) Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature 319(6050): 230-234
    2. Wang, Y. N. et al. (2012) Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2. J. Biol. Chem. 287(20): 16869-16879
    3. Tsutsui, S. et al. (2002) Prognostic value of c-erbB2 expression in breast cancer. J Surg Oncol 79(4): 216-223
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