Anti-EPHB4 antibodies, human

Anti-EPHB4 antibodies, human

Clone: REA923 | Dilution: 1:50
Clone REA923 recognizes the human ephrin type-B receptor 4 (EPHB4) antigen, which is a member of the Eph receptor tyrosine kinase family. The ligand for EPHB4 is ephrin-B2. EPHB4 is found in different tissues, e.g., in placenta, kidney, liver, lung, pancreas, skeletal muscle, and heart. It is expressed on myeloid hematopoietic cells and endothelial cells. EPHB4 functions as an inhibitor for cell-cell adhesion, chemotaxis, and angiogenesis as well as a promoter for the differentiation of megakaryocytic and erythroid progenitor cells.
Additional information: Clone REA923 displays negligible binding to Fc receptors.

Alternative names

Ephrin type-B receptor 4, Hepatoma transmembrane kinase, Tyrosine-protein kinase TYRO11, HTK, MYK1, TYRO11

Technical specifications

  • Antigen: EPHB4
  • Clone: REA923
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Ephrin type-B receptor 4, Hepatoma transmembrane kinase, Tyrosine-protein kinase TYRO11, HTK, MYK1, TYRO11
  • Entrez Gene ID: 2050
  • Molecular mass of antigen [kDa]: 107
  • Distribution of antigen: placenta, liver, lung, kidney, pancreas, skeletal muscle, breast, colon, endothelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Erber, R. et al. (2006) EphB4 controls blood vascular morphogenesis during postnatal angiogenesis. EMBO J. 25(3): 628-641
    2. Füller, T. et al. (2003) Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. J. Cell. Sci. 116(12): 2461-2470
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