Anti-Dnmt3b antibodies, human, mouse, rat

Anti-Dnmt3b antibodies, human, mouse, rat

Clone: REA565 | Dilution: 1:11
Clone REA565 recognizes the Dnmt3b antigen, which is a DNA methyltransferase, that performs
de novo
DNA methylation during embryonic development. It may function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation and may play a role in controlling the differentiation of human ES cells and in the generation of iPS cells. Dnmt3 is expressed ubiquitously, at higher levels expressed in mouse and human embryonic stem (ES), in fetal liver, heart, kidney, and placenta.
Additional information: Clone RE565 displays negligible binding to Fc receptors.

Alternative names

ICF, MmuIIIB, ICF1, M.HsaIIIB

Technical specifications

  • Antigen: Dnmt3b
  • Clone: REA565
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: ICF, MmuIIIB, ICF1, M.HsaIIIB
  • Entrez Gene ID: 1789, 444985
  • Molecular mass of antigen [kDa]: 96, 97
  • Distribution of antigen: ubiquitous
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, pure
  • Selected references

    1. Yajun, L. et al. (2010) Interaction between DNMT3B and polycomb repression complexes and their role in histone modification. Cancer Res. 70: 4868-4868
    2. Torroglosa, A. et al. (2014) Involvement of DNMT3B in the pathogenesis of Hirschsprung disease and its possible role as a regulator of neurogenesis in the human enteric nervous system. Genet. Med. 16(9): 703-710
    3. Wongtrakoongate, P. et al. (2014) DNMT3B inhibits the re-expression of genes associated with induced pluripotency. Exp. Cell Res. 321(2): 231-239
    4. Niederwieser, C. et al. (2015) Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia. Leukemia 29(3): 567-575
Product options: 5
for 30
tests
(1)
USD 97.00
for 100
tests
(1)
USD 272.00
for 30
tests
(1)
USD 124.00
for 100
tests
(1)
USD 288.00
100 µg in 1 mL
USD 148.00

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