Anti-CXCL10 (IP-10) antibodies, human

Anti-CXCL10 (IP-10) antibodies, human

Clone: REA334
Clone REA334 recognizes the human C-X-C motif chemokine 10 (CXCL10) antigen, a secreted molecule also known as interferon gamma-induced protein (IP-10). CXCL10 is a member of the CXC chemokine family which binds to the cell surface chemokine receptor CXCR3 to exert its biological effects. It is secreted by several cell types in response to IFN-γ. These cell types include monocytes, endothelial cells, and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, anti-tumor activity, and inhibition of bone marrow colony formation and angiogenesis. It is associated with a variety of human diseases including infectious diseases, chronic inflammation, immune dysfunction, tumor development, metastasis, and dissemination. CXCL10 has been identified as a major biological marker mediating disease severity and may be utilized as a prognostic indicator for various diseases.
Additional information: Clone REA334 displays negligible binding to Fc receptors.

Alternative names

C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1

Technical specifications

  • Antigen: CXCL10 (IP-10)
  • Clone: REA334
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1
  • Entrez Gene ID: 3627
  • Molecular mass of antigen [kDa]: 9
  • Distribution of antigen: monocytes, endothelial cells, fibroblasts
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates:
  • Selected references

    1. Luster, A. D. et al. (1985) Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 315(6021): 672-676
    2. Loos, T. et al. (2008) Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation Blood 112(7): 2648-2656
    3. Xu, W. et al. (2012) Macrophages induce differentiation of plasma cells through CXCL10/IP-10. J. Exp. Med. 209(10): 1813-1823
Product options: 1
100 µg in 100 µL
USD 180.00