Anti-ChemR23 (CMKLR1) antibodies, human

Anti-ChemR23 (CMKLR1) antibodies, human

Clone: REA455 | Dilution: 1:11
Clone REA455 recognizes the human G-protein–coupled receptor ChemR23 antigen, a multi-pass membrane protein which is also known as chemokine-like receptor 1 (CMKLR1). ChemR23 is expressed by leukocyte populations such as macrophages, immature myeloid and plasmacytoid dendritic cells, as well as on a subset of natural killer (NK) cells. Its natural ligand, chemerin, is a small protein isolated and identified from human inflammatory fluids which acts as a chemoattractant agent for leukocytes expressing ChemR23. Activation of ChemR23 results in intracellular calcium release, inhibition of cAMP accumulation, and phosphorylation of ERK-1/ERK-2 MAP kinases. Chemerin and ChemR23 are involved in the recruitment of NK and dendritic cells (DCs) into tissues in several human inflammatory diseases. They also participate to the regulation of adipocyte metabolism.
Additional information: Clone REA455 displays negligible binding to Fc receptors.

Alternative names

Cmklr1, CHEMERINR, Dez, RVER1

Technical specifications

  • Antigen: ChemR23 (CMKLR1)
  • Clone: REA455
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Cmklr1, CHEMERINR, Dez, RVER1
  • Entrez Gene ID: 1240
  • Molecular mass of antigen [kDa]: 42
  • Distribution of antigen: leukocytes, macrophages, dendritic cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Methner, A. et al. (1997) A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development. Biochem. Biophys. Res. Commun. 233(2): 336-342
    2. Samson, M. et al. (1998) ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains. Eur. J. Immunol. 28(5): 1689-1700
    3. Bondue, B. et al. (2012)
      The chemerin/ChemR23 system does not affect the pro-inflammatory response of mouse and human macrophages
      ex vivo
      .
      PLoS One 7(6): 400-443
Product options: 4
for 30
tests
(1)
USD 97.00
for 100
tests
(1)
USD 268.00
for 30
tests
(1)
USD 120.00
for 100
tests
(1)
USD 288.00

Related products

1 products available