Anti-c-Rel antibodies, mouse

Anti-c-Rel antibodies, mouse

Clone: REA397 | Dilution: 1:11
Clone REA397 recognizes the mouse c-Rel antigen, a 65 kDa member of the NF-κB family of eukaryotic transcription factors, which also includes the proteins RelA (p65), RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). NF-κB transcription factors can form various homo- and heterodimers possessing unique specificities in regulating target gene expression. While RelA-containing dimers are present in most cell types, c-Rel complexes are predominately found in cells of hematopoietic origin. In T cell lymphocytes, certain genes essential for immune function such as interleukin 2 (IL-2) and FoxP3 are directly regulated by c-Rel. Additionally, c-Rel-dependent IL-12 and IL-23 transcription by macrophages and dendritic cells (DCs) is crucial for T cell differentiation and effector functions. Accordingly, c-Rel expression in T cells and antigen-presenting cells controls a delicate balance between tolerance and immunity.
Additional information: Clone REA397 displays negligible binding to Fc receptors.

Alternative names

REL

Technical specifications

  • Antigen: c-Rel
  • Clone: REA397
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: REL
  • Entrez Gene ID: 19696
  • Molecular mass of antigen [kDa]: 65
  • Distribution of antigen: T cells, lymphocytes, dendritic cells, macrophages, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE
  • Selected references

    1. Gilmore, T. D. et al. (2004) The c-Rel transcription factor and B-cell proliferation: a deal with the devil. Oncogene 23(13): 2275-2286
    2. Grumont, R. J. et al. (1990) The murine c-rel proto-oncogene encodes two mRNAs the expression of which is modulated by lymphoid stimuli. Oncogene 5(4): 245-254
    3. Gonzalez-Perez, G. et al. (2017)
      Gastrointestinal microbiome dysbiosis in infant mice alters peripheral CD8
      +
      T cell receptor signaling.
      Front Immunol 8: 265
    4. Gonzalez-Perez, G. and Lamousé-Smith, E. S. (2017)
      Gastrointestinal microbiome dysbiosis in infant mice alters peripheral CD8
      +
      T cell receptor signaling.
      Front Immunol 8(8): 265
    5. Visekruna, A. et al. (2012) A key role for NF-κB transcription factor c-Rel in T-lymphocyte-differentiation and effector functions. Clin. Dev. Immunol. 2012: 239368
Product options: 2
9 µg in 300 µL (1)
USD 55.00
30 µg in 1 mL (1)
USD 75.00