Anti-β-Catenin antibodies, human and mouse

Anti-β-Catenin antibodies, human and mouse

Clone: REA480 | Dilution: 1:11
Clone REA480 recognizes the human and mouse β-catenin antigen, a 92 kDa dual function protein regulating the coordination of cell-cell adhesion and gene transcription. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. As a component of adherens junctions, β-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor adenomatous polyposis coli (APC). Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors as well as ovarian and endometrial cancer.
Additional information: Clone REA480 displays negligible binding to Fc receptors.

Alternative names

CTNNB1, CTNNB, MRD19, armadillo, CTNB1, Beta-catenin, Catnb

Technical specifications

  • Antigen: β-Catenin
  • Clone: REA480
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: CTNNB1, CTNNB, MRD19, armadillo, CTNB1, Beta-catenin, Catnb
  • Entrez Gene ID: 1499, 12387
  • Molecular mass of antigen [kDa]: 85
  • Distribution of antigen: endothelial cells, epithelial cells, keratinocytes, fibroblasts, ubiquitous, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, FITC
  • Selected references

    1. Butz, S. et al. (1992) Plakoglobin and beta-catenin: distinct but closely related. Science 257(5073): 1142-1144
    2. MacDonald, B. T. et al. (2009) Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev. Cell 17(1): 9-26
    3. Clevers, H. et al. (2012) Wnt/β-catenin signaling and disease. Cell 149(6): 1192-1205
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