CD56 MicroBeads, human

CD56 MicroBeads, human

CD56 MicroBeads were developed for the positive selection or depletion of natural killer (NK) cells from human PBMCs or single-cell suspensions from tissues. The CD56 antigen is expressed by most NK cells and a minor T cell subset (CD3
+
CD56
+
NKT cells). Upon activation of NK cells, the surface expression of CD56 is increased.

Downstream applications

CD56
+
cells are used in studies on NK cell development, proliferation, or cytotoxic activity as well as in analysis of signal transduction and related molecular processes
1–3
.
CD56 may also be used for the enrichment of embryonic stem cell–derived cardiomyocytes cells after
in vitro
differentiation
4
as well as the direct selection stem and progenitor cells from muscle tissue
5,6
.

Columns

For positive selection: MS, LS, XS, or autoMACS
®
Columns. For depletion: LD, D, or autoMACS Columns.
  • Selected references

    1. Fletcher, J. M. et al. (1998) Natural killer cell lysis of cytomegalovirus (CMV)-infected cells correlates with virally induced changes in cell surface lymphocyte function-associated antigen-3 (LFA-3) expression and not with the CMV-induced down-regulation of cell surface class I HLA. J. Immunol. 161: 2365-2374
    2. Doherty, D. G. et al. (1999)
      The human liver contains multiple populations of NK cells, T cells, and CD3
      +
      CD56
      +
      natural T cells with distinct cytotoxic activities and Tʜ1, Tʜ2, and Tʜ0 cytokine secretion patterns.
      J. Immunol. 163: 2314-2321
    3. Kumaki, S. et al. (2001) Identification of anti-herpes simplex virus antibody-producing B cells in a patient with an atypical RAG1 immunodeficiency. Blood 98: 1464-1468
    4. Xu, S. et al. (2006) Cardiac bodies: a novel culture method for enrichment of cardiomyocytes derived from human embryonic stem cells. Stem Cells Dev. 15: 631-639
    5. Sinanan, A. et al. (2004) Human adult craniofacial muscle-derived cells: neural-cell adhesion-molecule (NCAM; CD56)-expressing cells appear to contain multipotential stem cells. Biotechnol. Appl. Biochem. 40: 25-34
    6. De Luna, N. et al. (2006)
      Absence of dysferlin alters myogenin expression and delays human muscle differentiation
      in vitro
      .
      J. Biol. Chem. 281: 17092-17098
  • Brochures and posters

Product options: 2
for 1×
10
9
total cells
USD 665.00
for 1×
10
9
total cells
USD 670.00

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