Connective tissue growth factor (CTGF) is a member of the CCN family and involved in cell adhesion of fibroblasts, migration, proliferation, and angiogenesis. It is produced by the umbilical vein, vascular endothelial cells, and glial cells. CTGF is also involved in fibrotic disease and several forms of cancers. In zebrafish it was shown that CTGF is involved in spinal cord repair.
CTGF comprises four different domains. An insulin-like growth factor (IGF)-binding domain, a von Willebrand type C (VWC) domain, a thrombospondin-1 (TSP-1) domain, and a C-terminal cystine knot-like domain. The individual domains can regulate different cellular functions and certain domains can act interdependently.