Human BMP-7

Human BMP-7

BMP-7 stands for bone morphogenetic protein 7. Human BMP-7 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human BMP-7 can be used for a variety of applications, including:
  • Mesenchymal cell cultures.
  • In vitro studies of bone and cartilage development.
  • Investigation of SMAD signaling.

Background information

Bone morphogenetic protein 7 (BMP-7) belongs to the BMP family and to the transforming growth factor β (TGF-β) superfamily. BMPs regulate bone and cartilage development and remodeling, acting on cell proliferation, differentiation, and apoptosis of mesenchymal cells. The mature form of BMP-7 is generated by cleavage of the signal peptide and propeptide, and homo-dimerization. BMP-7 is involved in osteoblast differentiation, but also in the regulation of tissue and organ development during embryogenesis of different species, and it is expressed in many organs. BMP-7 is extensively investigated for clinical applications, and recombinant BMP-7 is used in bone regeneration, bone graft, and dental reconstruction. Recombinant Human BMP-7 corresponds to the mature form of BMP-7.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Alkaline phosphatase activity assay using MC3T3-E1 cells
  • research grade: ≥ 1×
    10
    4
    U/mg
  • Certificates

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Product options: 3
CHO cells
10 µg
USD 245.00
CHO cells
100 µg
USD 1,670.00
CHO cells
1000 µg
USD 9,470.00