Visualization of single disseminated tumor cells in whole mouse body

In the study published in Cell, the group of Ali Ertürk from the Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Zentrum München, Germany used the UltraMicroscope Blaze to identify hundreds of small metastases throughout the mouse body.

These disseminated tumor cells were otherwise undetectable by other methods. The UltraMicroscope Blaze also enabled them to see exactly which metastasis was targeted by a drug candidate and which one was missed.

According to the researchers, this method could significantly increase the success rate of cancer drug candidates.

Pan, C. et al. (2019) Cell 179: 1661–1676.e19. (PMID:31835038).

Video

Imaging single cancer cells disseminated in whole mouse bodies

Source: Chenchen Pan et al, Deep learning reveals cancer metastasis and therapeutic antibody targeting in the entire body, P1661–1676.E19.,
Copyright (2019), with permission from Elsevier.

Director of iTERM, Helmholtz Zentrum München, Germany

Dr. Ali Ertürk

“The UltraMicroscope Blaze allows us to see every single cancer metastasis in the whole bodies of transparent mice and we can also see if drugs are targeting all those tiny micro-metastases. The UltraMicroscope Blaze will be a powerful tool for drug development in oncology.”

UltraMicroscope Blaze applications in immuno-oncology research

• Visualization of single disseminated cancer cells in whole animal models

• Drug target identification for cancer treatments in a whole mouse body or entire organs

• Section-free 3D histological analysis

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