Breaking down the walls to GMP cell manufacturing

The promise of cell and gene therapy is great, but not without its challenges. Complex processes, such as chimeric antigen receptor (CAR) T cell manufacturing, often require multiple steps that are performed across several devices. Unfortunately, hands-on manipulations like cell transfer between vessels and manual pipetting, always carry the the risk of contamination, human error, and cell loss.

The CliniMACS Prodigy® Platform automates cell processing from starting material to final cellular product in a single instrument. All major cell manufacturing steps are automated and standardized for increased reproducibility in a closed system to enable the production of GMP-compliant cell products.

A variety of cell manufacturing procedures are made possible by the CliniMACS Prodigy, including:

• Automated generation of CAR T cells
• Ex vivo GMP-compliant antigen loading of dendritic cells
• Automated manufacturing of antigen-specific T cells