Clone REAL103 is an antibody fragment derived from the full CD4 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL103 recognizes the human CD4 antigen, a 55 kDa single-pass type I membrane protein also known as T4 or Leu-3. CD4 is highly expressed on T helper cells and at a lower level on monocytes and dendritic cells. It is involved in the recognition of MHC class II/peptide complexes by the TCR heterodimers and is the receptor for the human immunodeficiency virus (HIV).
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative Names

CD4mut, L3T4, Leu-3, T4

Technical specifications

  • Antigen: CD4
  • Clone: REAL103
  • Isotype control: REAL Control
  • Alternative names of antigen: CD4mut, L3T4, Leu-3, T4
  • Distribution of antigen: T helper cells, monocytes, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PerCP
  • Selected References

    1. Maddon, P. J. et al. (1985) The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family. Cell 42(1): 93-104
    2. Barclay, A. N. et al. (1993) CD4 and the immunoglobulin superfamily. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 342(1299): 7-12
    3. Tebas, P. et al. (2014) Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N. Engl. J. Med. 370(10): 901-910
Product options: 17

Product information

Size
Order no.
Price

REAlease CD4-FITC, human

  • REAL103
  • 1:50
  • For research use only
for 30
tests
(1)
130-112-245
-

REAlease CD4-FITC, human

  • REAL103
  • 1:50
  • For research use only
for 100
tests
(1)
130-112-071
-

REAlease CD4-PE, human

  • REAL103
  • 1:50
  • For research use only
for 30
tests
(1)
130-117-837
-

REAlease CD4-PE, human

  • REAL103
  • 1:50
  • For research use only
for 100
tests
(1)
130-117-725
-

REAlease CD4-APC, human

  • REAL103
  • 1:50
  • For research use only
for 30
tests
(1)
130-112-256
-

REAlease CD4-APC, human

  • REAL103
  • 1:50
  • For research use only
for 100
tests
(1)
130-112-089
-

REAlease CD4-VioBlue, human

  • REAL103
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-119
-

REAlease CD4-VioBlue, human

  • REAL103
  • 1:50
  • For research use only
for 100
tests
(1)
130-118-942
-

REAlease CD4-VioGreen, human

  • REAL103
  • 1:50
  • For research use only
for 30
tests
(1)
130-115-552
-

REAlease CD4-VioGreen, human

  • REAL103
  • 1:50
  • For research use only
for 100
tests
(1)
130-115-434
-

REAlease CD4-PerCP, human

  • REAL103
  • 1:50
  • For research use only
for 30
tests
(1)
130-121-267
-

REAlease CD4-PerCP, human

  • REAL103
  • 1:50
  • For research use only
for 100
tests
(1)
130-121-182
-

REAlease CD4-FITC Kit, human

  • REAL103
  • 1:50
  • For research use only
for 100
tests
(1)
130-122-676
-

REAlease CD4-PE Kit, human

  • REAL103
  • 1:50
  • For research use only
for 100
tests
(1)
130-122-677
-

REAlease CD4-APC Kit, human

  • REAL103
  • 1:50
  • For research use only
for 100
tests
(1)
130-122-678
-

REAlease CD4-VioBlue Kit, human

  • REAL103
  • 1:50
  • For research use only
for 100
tests
(1)
130-122-679
-

REAlease CD4-VioGreen Kit, human

  • REAL103
  • 1:50
  • For research use only
for 100
tests
(1)
130-122-680
-