REAlease® CD11b Complexes, mouse

REAlease
®
CD11b Complexes
, mouse

Clone: REAL113 | Dilution: 1:50
Clone REAL113 is an antibody fragment derived from the full CD11b antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL113 recognizes the human and mouse CD11b antigen (Mac-1 α; integrin αM chain), which is part of the CD11b/CD18 heterodimer (Mac-1 α, Mβ2 integrin), also known as the C3 complement receptor. It functions as a receptor for complement (C3bi), fibrinogen, or clotting factor X. In humans, CD11b is strongly expressed on myeloid cells and weakly expressed on natural killer (NK) cells and some activated lymphocytes as well as on microglia in the brain. In mice, the CD11b antigen is expressed on monocytes/macrophages and microglia. To a lower extent it is expressed on granulocytes, NK cells, CD5
+
B-1 cells, and subsets of dendritic cells. Clone REAL113 recognizes also the non-human primate CD11b antigen.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative Names

integrin αM, Mac-1 α, Integrin alpha-M, CR3A, ITGAM, MAC1A, MO1A, SLEB6

Technical specifications

  • Antigen: CD11b
  • Clone: REAL113
  • Isotype control: REAL Control
  • Alternative names of antigen: integrin αM, Mac-1 α, Integrin alpha-M, CR3A, ITGAM, MAC1A, MO1A, SLEB6
  • Cross-reactivity: non-human primate
  • Distribution of antigen: myeloid cells, NK cells, lymphocytes, microglia, brain
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PerCP
  • Selected References

    1. Pahl, H. L. et al. (1992) Characterization of the myeloid-specific CD11b promoter. Blood 79(4): 865-870
    2. Lebson, L. et al. (2010) Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice. J. Neurosci. 30(29): 9651-9658
    3. Liu, T. et al. (2014)
      Gr-1
      +
      CD11b
      +
      cells facilitate Lewis lung cancer recurrence by enhancing neovasculature after local irradiation.
      Sci. Rep. 4: 4833
Product options: 1

Product information

Size
Order no.
Price

REAlease CD11b-PerCP, mouse

  • REAL113
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-121-185
-