CD95 (FAS) antibodies, human

CD95 (FAS) antibodies, human

Clone: REA738 | Dilution: 1:50
Clone REA738 recognizes the human CD95 antigen, also known as Fas and Apo-1, which is a member of the tumor necrosis factor receptor superfamily (TNFR) and is found on the surface of many normal and neoplastically transformed cells. Its ligand, CD95L (FasL/Apo-1L), is able to induce apoptosis in CD95-expressing cells upon binding. CD95 and CD95L are up-regulated on lymphocytes upon activation and are known to play a key role in the regulation of an inflammatory response: Juxtocrine “fratricide” of neighbouring lymphocytes via mutual CD95 and CD95L expression helps to terminate immune responses, while apoptosis of pro-inflammatory cells via CD95 helps maintain immune privilege in sites such as the eye, where CD95L is found to be expressed in the retina and cornea. Cross-linking of CD95 receptors by DX2 monoclonal antibody has been described to induce apoptosis in certain target cells.
Additional information: Clone REA738 displays negligible binding to Fc receptors.

Alternative Names

FAS, ALPS1A, APO-1, Apt1, FAS1, FASTM, Tnfrsf6

Technical specifications

  • Antigen: CD95 (FAS)
  • Clone: REA738
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: FAS, ALPS1A, APO-1, Apt1, FAS1, FASTM, Tnfrsf6
  • Entrez Gene ID: 355
  • Molecular mass of antigen [kDa]: 35
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    rhesus monkey (
    Macaca mulatta
    )
    ,
    african green monkey (
    Chlorocebus aethiops
    )
    , baboon, capuchin monkey,
    chimpanzee (
    Pan troglodytes
    )
    ,
    common marmoset (
    Callithrix jacchus
    )
    ,
    cotton-top tamarin (
    Saguinus oedipus
    )
    ,
    pigtail monkey (
    Macaca nemestrina
    )
    ,
    sooty mangabey (
    Cercocebus atys
    )
  • Distribution of antigen: lymphocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, VioBright 515, Biotin
Product options: 15

Product information

Size
Order no.
Price

CD95 (FAS)-FITC, human

  • REA738
  • 1:50
  • For research use only
for 30
tests
(1)
130-113-068
-

CD95 (FAS)-FITC, human

  • REA738
  • 1:50
  • For research use only
for 100
tests
(1)
130-113-003
-

CD95 (FAS)-PE, human

  • REA738
  • 1:50
  • For research use only
for 30
tests
(1)
130-113-069
-

CD95 (FAS)-PE, human

  • REA738
  • 1:50
  • For research use only
for 100
tests
(1)
130-113-004
-

CD95 (FAS)-APC, human

  • REA738
  • 1:50
  • For research use only
for 30
tests
(1)
130-113-070
-

CD95 (FAS)-APC, human

  • REA738
  • 1:50
  • For research use only
for 100
tests
(1)
130-113-005
-

CD95 (FAS)-PE-Vio615, human

  • REA738
  • 1:50
  • For research use only
for 30
tests
(1)
130-113-074
-

CD95 (FAS)-PE-Vio615, human

  • REA738
  • 1:50
  • For research use only
for 100
tests
(1)
130-113-009
-

CD95 (FAS)-PE-Vio770, human

  • REA738
  • 1:50
  • For research use only
for 30
tests
(1)
130-113-071
-

CD95 (FAS)-PE-Vio770, human

  • REA738
  • 1:50
  • For research use only
for 100
tests
(1)
130-113-006
-

CD95 (FAS)-APC-Vio770, human

  • REA738
  • 1:50
  • For research use only
for 100
tests
(1)
130-113-007
-

CD95 (FAS)-VioBright 515, human

  • REA738
  • 1:50
  • For research use only
for 30
tests
(1)
130-113-073
-

CD95 (FAS)-VioBright 515, human

  • REA738
  • 1:50
  • For research use only
for 100
tests
(1)
130-113-008
-

CD95 (FAS)-Biotin, human

  • REA738
  • 1:50
  • For research use only
for 30
tests
(1)
130-113-067
-

CD95 (FAS)-Biotin, human

  • REA738
  • 1:50
  • For research use only
for 100
tests
(1)
130-113-002
-

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