CD94 antibodies, mouse

CD94 antibodies, mouse

Clone: 18d3 | Dilution: 1:10
Clone 18d3 recognizes CD94, an approximately 70 kDa, single pass, type II transmembrane protein, which belongs to C-type lectin superfamily. CD94 associates covalently with NKG2 family members and forms disulfide bonded heterodimers. CD94-NKG2 receptors bind HLA-E, the nonclassical MHC class Ib molecule. Depending on the associated NKG2 member, CD94-NKG2 heterodimer transmits either activating or inhibitory signal. For e.g via immunoreceptor tyrosine based-inhibitory motifs (ITIMs) containing NKG2A, CD94-NKG2A heterodimers inhibit NK cell cytotoxicity. Besides NK cells, expression of CD94-NKG2 heterodimers is also shown on NK-T cells and a small percentage of CD8
+
cells in most mouse strains. DBA/2J mice do not express CD94.

Alternative Names

KLRD1, Kp43

Technical specifications

  • Antigen: CD94
  • Clone: 18d3
  • Isotype: rat IgG2aκ
  • Isotype control: Rat IgG2a – isotype control antibodies
  • Alternative names of antigen: KLRD1, Kp43
  • Entrez Gene ID: 16643
  • Molecular mass of antigen [kDa]: 20,8
  • Distribution of antigen: NKT cells, T cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, APC-Vio770, Biotin
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