CD9 antibodies, human

CD9 antibodies, human

Clone: REA1071 | Dilution: 1:50
Clone REA1071 recognizes the human CD9 antigen, a 25 kDa cell surface glycoprotein which is also known as tetraspanin-29 (Tspan-29). CD9 belongs to the tetraspanin family of integral proteins, which are characterized by the presence of four conserved transmembrane domains, a small and two large extracellular loops. Expression of CD9 is found on platelets, pre–B cells, fibroblasts, eosinophils, macrophages, basophils, epithelial cells, oocytes, and activated T cells. Further expression is reported on malignant cells and tumor cell lines where CD9 is involved in supressor functions, inhibition of cell invasion and metastasis. CD9 associates with other tetraspanin members, cell adhesion molecules such as EpCAM, integrin subsets, transmembrane proteins (EWI-2 and EWI-F), choline receptors, and G-proteins. Through diverse interactions or via direct stimulation, CD9 influences various cellular functions including cell adhesion, aggregation, migration, clustering of MHC molecules in dendritic cells (DCs), and provides costimulatory signal during T cell activation.
Additional information: Clone REA1071 displays negligible binding to Fc receptors.

Alternative Names

5H9, MRP-1, Tetraspanin-29 (Tspan-29), TSPAN-29, p24, MIC3, Tspan29, ORF, GIG2

Technical specifications

  • Antigen: CD9
  • Clone: REA1071
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: 5H9, MRP-1, Tetraspanin-29 (Tspan-29), TSPAN-29, p24, MIC3, Tspan29, ORF, GIG2
  • Entrez Gene ID: 928
  • Molecular mass of antigen [kDa]: 25
  • Distribution of antigen: B cells, basophils, eosinophils, epithelial cells, fibroblasts, granulocytes, macrophages, platelets, T cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
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