CD8b antibodies, human

CD8b antibodies, human

Clone: REA715 | Dilution: 1:50
Clone REA715 recognizes the human CD8b antigen, a single-pass type I membrane protein and member of the immunoglobulin superfamily, also known as T cell surface glycoprotein Lyt-3. The CD8 glycoprotein is expressed by thymocytes, mature T cells, and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex class I antigens and in signal transduction during the course of T cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. Most of peripheral blood CD8
T lymphocytes express the CD8a/CD8b heterodimer, while CD8
natural killer cells and CD8
T cell receptor γ/δ
T lymphocytes express only the CD8a/CD8a homodimer. CD8b can therefore be used to selectively bind to CD8
T cells while excluding CD8
NK cells.
Additional information: Clone REA715 displays negligible binding to Fc receptors.

Alternative Names

CD8 beta chain, CD8 b chain, CD8b

Technical specifications

  • Antigen: CD8b
  • Clone: REA715
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CD8 beta chain, CD8 b chain, CD8b
  • Entrez Gene ID: 926
  • Molecular mass of antigen [kDa]: 21
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
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