CD89 antibodies, human

CD89 antibodies, human

Clone: REA234 | Dilution: 1:11
Clone REA234 recognizes CD89, the human myeloid IgA Fc receptor. CD89 is a glycosylated transmembrane protein that binds both IgA subclasses (IgA1 and IgA2) and is closely related to the KIR and MIR proteins rather than to other human Fc receptors. CD89 itself lacks the canonical signal transduction domains, however it associates with the FcR γ-chain with an immunoreceptor tyrosine-based activation (ITAM) motif, which allows transduction of activation signal upon ligand binding. FcαRI alone mediates endocytosis and recyling of IgA. Expression of CD89 is found on neutrophils, eosinophils, monocytes/macrophages, dendritic cells, and Kupffer cells.
Additional information: Clone REA234 displays negligible binding to Fc receptors.

Alternative Names

FCAR

Technical specifications

  • Antigen: CD89
  • Clone: REA234
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: FCAR
  • Distribution of antigen: monocytes, macrophages, dendritic cells, eosinophils, neutrophils
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected References

    1. Wu, J. et al. (2007) FcαRI (CD89) alleles determine the proinflammatory potential of serum IgA. J. Immunol. 178: 3973-3982
    2. Morton, H. C. et al. (1995) Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR chain. J. Biol. Chem. 270: 29781-29787
Product options: 12
130-101-387

CD89-FITC, human

for 30
tests
(1)
-
130-101-385

CD89-FITC, human

for 100
tests
(1)
-
130-101-388

CD89-PE, human

for 30
tests
(1)
-
130-101-386

CD89-PE, human

for 100
tests
(1)
-
130-101-384

CD89-APC, human

for 30
tests
(1)
-
130-101-383

CD89-APC, human

for 100
tests
(1)
-
130-101-369

CD89-PE-Vio770, human

for 30
tests
(1)
-
130-101-366

CD89-PE-Vio770, human

for 100
tests
(1)
-
130-101-364

CD89-APC-Vio770, human

for 30
tests
(1)
-
130-101-361

CD89-APC-Vio770, human

for 100
tests
(1)
-
130-101-373

CD89-Biotin, human

for 30
tests
(1)
-
130-101-370

CD89-Biotin, human

for 100
tests
(1)
-