CD89 antibodies – functional grade, human

CD89 antibodies – functional grade, human

Clone: REA234
Clone REA234 recognizes CD89, the human myeloid IgA Fc receptor. CD89 is a glycosylated transmembrane protein that binds both IgA subclasses (IgA1 and IgA2) and is closely related to the KIR and MIR proteins rather than to other human Fc receptors. CD89 itself lacks the canonical signal transduction domains, however it associates with the FcR γ-chain with an immunoreceptor tyrosine-based activation (ITAM) motif, which allows transduction of activation signal upon ligand binding. FcαRI alone mediates endocytosis and recyling of IgA. Expression of CD89 is found on neutrophils, eosinophils, monocytes/macrophages, dendritic cells, and Kupffer cells.
Additional information: Clone REA234 displays negligible binding to Fc receptors.

Applications

This pure – functional grade antibody is suited for cell culture functional assays, for example, blocking of receptor-ligand binding.

Alternative Names

FCAR, CTB-61M7.2, FcαRI

Technical specifications

  • Antigen: CD89
  • Clone: REA234
  • Isotype: recombinant human IgG1
  • Alternative names of antigen: FCAR, CTB-61M7.2, FcαRI
  • Distribution of antigen: monocytes, macrophages, dendritic cells, eosinophils
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
Product options: 1

Product information

Size
Order no.
Price

CD89 pure - functional grade, human

  • REA234
  • For research use only
500 µg in 0.5 mL
130-101-089
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