CD88 (C5AR) antibodies, human

CD88 (C5AR) antibodies, human

Clone: S5/1 | Dilution: 1:11
Clone S5/1 recognizes the human CD88 antigen, a 43 kDa G type protein–coupled receptor with seven membrane-spanning regions which is also known as C5a anaphylatoxin chemotactic receptor 1 (C5AR). CD88 expression is originally described on neutrophils and monocyte/macrophages, but it is also found on hepatocytes, epithelial cells, endothelial cells, tissue mast cells, and human fetal astrocytes. Constitutive CD88 expression was also detected on astrocytes, microglia, and fibroblast-like cells but not by oligodendrocytes. CD88 is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. It stimulates chemotaxis, granule enzyme release, and superoxide anion production. Sulfation plays a critical role in the association of CD88 with C5a, but no significant role in the ability of CD88 to transduce a signal and mobilize calcium in response to a small peptide agonist.

Alternative Names

C5AR1, C5A, C5AR, C5R1

Technical specifications

  • Antigen: CD88 (C5AR)
  • Clone: S5/1
  • Isotype: mouse IgG2aκ
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: C5AR1, C5A, C5AR, C5R1
  • Entrez Gene ID: 728
  • Molecular mass of antigen [kDa]: 39
  • Distribution of antigen: neutrophils, monocytes, macrophages, endothelial cells, epithelial cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
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