CD87 antibodies, human

CD87 antibodies, human

Clone: VIM5 | Dilution: 1:11
Clone VIM5 recognizes CD87, a 36–38 kDa GPI-anchored cell-surface receptor. CD87, also known uPAR, binds uPA and thus facilitating the catalytic C domain of the uPA to come in close proximity of membrane bound plasminogen. uPA is a serine protease, which converts plasminogen into plasmin which in-turn is involved in digestion of various extracellular matrix proteins. CD87 belongs to the Ly6/neurotoxin receptor family and consists of three disulfide-bonded homologous domains, D1, D2, and D3. Function of uPAR is modulated by two inhibitors, PA1 and PA2. The expression of membrane-bound CD87 is found on granulocytes, monocytes/macrophages, dendritic cells, fibroblasts, endothelial cells, and keratinocytes. Multiple known regulatory functions of CD87 include cell migration, leukocyte adhesion, chemotaxis, signal transduction, and tissue remodeling.

Alternative Names

PLAUR, U-PAR, URKR

Technical specifications

  • Antigen: CD87
  • Clone: VIM5
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: PLAUR, U-PAR, URKR
  • Entrez Gene ID: 5329
  • Molecular mass of antigen [kDa]: 31
  • Cross-reactivity:
    chimpanzee (
    Pan troglodytes
    )
  • Distribution of antigen: granulocytes, monocytes, dendritic cells, fibroblasts, endothelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770
  • Selected References

    1. May, A. E. et al. (1998)
      Urokinase receptor (CD87) regulates leukocyte recruitment via β2 integrins
      in vivo
      .
      J. Exp. Med. 188: 1029-1037
    2. Tarui, T. et al. (2001) Urokinase-type plasminogen activator receptor (CD87) is a ligand for integrins and mediates cell-cell interaction. J. Biol. Chem. 276: 3983-3990
    3. Ge, Y. et al. (2003) Urokinase plasminogen activator receptor (CD87): something old, something new. Lab. Hematol. 9(2): 67-71
Product options: 10
130-099-472

CD87-FITC, human

for 30
tests
(1)
-
130-099-468

CD87-FITC, human

for 100
tests
(1)
-
130-099-458

CD87-PE, human

for 30
tests
(1)
-
130-099-461

CD87-PE, human

for 100
tests
(1)
-
130-099-470

CD87-APC, human

for 30
tests
(1)
-
130-099-456

CD87-APC, human

for 100
tests
(1)
-
130-099-447

CD87-PE-Vio770, human

for 30
tests
(1)
-
130-099-452

CD87-PE-Vio770, human

for 100
tests
(1)
-
130-099-444

CD87-APC-Vio770, human

for 30
tests
(1)
-
130-099-445

CD87-APC-Vio770, human

for 100
tests
(1)
-