CD86 antibodies, mouse

Clone: PO3.3 | Dilution: 1:50
Antibody clone PO3.3 detects the CD86 antigen, also known as B7-2, an 80 kDa molecule and a member of the immunoglobulin superfamily. Together with CD80 (B7-1) it belongs to the B7 family of costimulatory molecules. CD86 is expressed on activated antigen-presenting cells, including B cells, dendritic cells, and monocytes/macrophages. The interaction of CD86 with its ligands CD28 and CD152 (CTLA- 4) plays a critical role in induction and regulation of immune responses, e.g., cross-talk between T and B cells, T cell costimulation, or immunoglobulin class-switching. Binding of CD86 to CD28 on T cells results in transduction of costimulatory signals for activation or proliferation of T cells, or cytokine production. In contrast, binding of CD86 to CTLA-4 regulates T cell activation and diminishes the immune response.

Alternative Names

B7-2, B70, CLS1, Cd28l2, ETC-1, Ly-58, MB7-2, TS/A-2

Technical specifications

  • Antigen: CD86
  • Clone: PO3.3
  • Isotype: rat IgG2bκ
  • Isotype control: Rat IgG2b – isotype control antibodies
  • Alternative names of antigen: B7-2, B70, CLS1, Cd28l2, ETC-1, Ly-58, MB7-2, TS/A-2
  • Entrez Gene ID: 12524
  • Molecular mass of antigen [kDa]: 32
  • Distribution of antigen: B cells, dendritic cells, endothelial cells, Langerhans cells, monocytes, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio770

Related products

2 products available
Product options: -

Product information

Size
Order no.
Price