CD86 antibodies, human

CD86 antibodies, human

Clone: REA968 | Dilution: 1:50
Clone REA968 recognizes the human CD86 antigen, also known as B7-2 or B70, which is an 80 kDa molecule and a member of the immunoglobulin superfamily. Together with CD80 (B7-1) it belongs to the B7 family of co-stimulatory molecules. CD86 is expressed on activated B and T cells, dendritic cells, and monocytes/macrophages. The interaction of CD86 with its ligands CD28 and CD152 (CTLA- 4) plays a critical role in induction and regulation of immune responses, e.g., cross-talk between T and B cells, T cell costimulation, or immunoglobulin class-switching. Binding of CD86 to CD28 on T cells results in transduction of costimulatory signals for activation or proliferation of T cells or cytokine production.
Additional information: Clone REA968 displays negligible binding to Fc receptors.

Alternative names

B7-2, B70, CD28LG2, LAB72

Technical specifications

  • Antigen: CD86
  • Clone: REA968
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: B7-2, B70, CD28LG2, LAB72
  • Entrez Gene ID: 942
  • Molecular mass of antigen [kDa]: 35
  • Distribution of antigen: B cells, dendritic cells, Langerhans cells, macrophages, monocytes, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected references

    1. Azuma, M. et al. (1993) B70 antigen is a second ligand for CTLA-4 and CD28. Nature 366(6450): 76-79
    2. Engel, P. et al. (1994) The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen. Blood 84(5): 1402-1407
    3. Lanier, L. L. et al. (1995) CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J. Immunol. 154(1): 97-105
Product options: 19
130-116-262

CD86-FITC, human

for 30
tests
(1)
-
130-116-159

CD86-FITC, human

for 100
tests
(1)
-
130-116-263

CD86-PE, human

for 30
tests
(1)
-
130-116-160

CD86-PE, human

for 100
tests
(1)
-
130-116-264

CD86-APC, human

for 30
tests
(1)
-
130-116-161

CD86-APC, human

for 100
tests
(1)
-
130-116-269

CD86-VioBlue, human

for 30
tests
(1)
-
130-116-166

CD86-VioBlue, human

for 100
tests
(1)
-
130-116-270

CD86-PE-Vio615, human

for 30
tests
(1)
-
130-116-167

CD86-PE-Vio615, human

for 100
tests
(1)
-
130-116-265

CD86-PE-Vio770, human

for 30
tests
(1)
-
130-116-162

CD86-PE-Vio770, human

for 100
tests
(1)
-
130-116-163

CD86-APC-Vio770, human

for 100
tests
(1)
-
130-116-267

CD86-PerCP-Vio700, human

for 30
tests
(1)
-
130-116-164

CD86-PerCP-Vio700, human

for 100
tests
(1)
-
130-116-268

CD86-VioBright 515, human

for 30
tests
(1)
-
130-116-165

CD86-VioBright 515, human

for 100
tests
(1)
-
130-116-261

CD86-Biotin, human

for 30
tests
(1)
-
130-116-158

CD86-Biotin, human

for 100
tests
(1)
-