CD85d (ILT4) antibodies, human

CD85d (ILT4) antibodies, human

Clone: REA184 | Dilution: 1:11
Clone REA184 recognizes CD85d, also known as immunoglobulin-like transcript 4 (ILT4) or leukocyte Ig-like receptor 2 (LIR2). CD85d is an inhibitory immunoreceptor, expressed mainly on myelomonocytic lineage cells.
CD85d has four tandem Ig-like extracellular domains and three immunoreceptor tyrosine-based inhibitory receptor motifs in its cytoplasmic tails, which recruit the tyrosine phosphatase Src homology 2 domain containing phosphatase 1 (SHP-1). It has been shown that CD85d interacts with HLA-A, -B, -G1, and -E molecules as ligands. HLA-G expression is restricted to trophoblasts and thus interaction of CD85d with HLA-G is suggested to inhibit placental leukocytes, contributing to maternal tolerance of the fetal semiallograft.
Additional information: Clone REA184 displays negligible binding to Fc receptors.

Alternative Names


Technical specifications

  • Antigen: CD85d (ILT4)
  • Clone: REA184
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: LILRB2, ILT-4, LIR2, MIR-10
  • Entrez Gene ID: 10288
  • Molecular mass of antigen [kDa]: 63
  • Distribution of antigen: monocytes, granulocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
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