CD80 antibodies, human

Clone: REA661 | Dilution: 1:50
Clone REA661 recognizes the human CD80 antigen, also known as B7-1. CD80 is a 262 amino acid long 60 kDa molecule and a member of the immunoglobulin superfamily. Together with CD86 (B7-2) it belongs to the B7 family of costimulatory molecules. CD80 is expressed on activated B cells, dendritic cells, and monocytes/ macrophages. The interaction of CD80 with its ligands CD28 and CD152 (CTLA-4) plays a critical role in induction and regulation of immune responses. Binding of CD80 to CD28, which is constitutively expressed on T cells, provides a co-stimulatory signal and induces T cell proliferation and cytokine production. In contrast, binding to CTLA-4 strongly inhibits proliferation and IL-2 secretion by T cells.
Additional Information: Clone REA661 displays negligible binding to Fc receptors.

Alternative Names

B7, B7-1, BB1

Technical specifications

  • Antigen: CD80
  • Clone: REA661
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: B7, B7-1, BB1
  • Entrez Gene ID: 941
  • Molecular mass of antigen [kDa]: 29
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: B cells, dendritic cells, Langerhans cells, macrophages, monocytes, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC
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