CD79b antibodies, mouse

CD79b antibodies, mouse

Clone: HM79-12 | Dilution: 1:10
Clone HM79-12 recognizes the mouse CD79b antigen, a 35-40kD Single-pass type I membrane protein also known as B-cell antigen receptor complex-associated protein beta chain (Igβ chain). The heterodimeric CD79 molecule is composed of an α chain (CD79a) and a β chain (CD79b) and is associated with surface immunoglobulins to form the B cell receptor. The CD79a/CD79b heterodimer facilitates the differentiation of pre-B cells from pro-B cells, surface expression of surface Ig, signal transduction following antigen recognition and endocytosis of recognized antigens. Crosslinking of CD79b in vitro by monoclonal antibodies activates pre-B cells but blocks terminal differentiation of all plasma cell isotypes. It was shown that a combination of CD79α and CD79β monoclonal antibodies can effectively deplete B cells from peripheral blood, spleen, bone marrow, and lymph nodes in mice.

Alternative Names

B29, Igbeta, Igb

Technical specifications

  • Antigen: CD79b
  • Clone: HM79-12
  • Isotype: hamster IgG
  • Alternative names of antigen: B29, Igbeta, Igb
  • Entrez Gene ID: 15985
  • Molecular mass of antigen [kDa]: 23
  • Distribution of antigen: B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, APC-Vio770, Biotin
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