CD79b antibodies, mouse

CD79b antibodies, mouse

Clone: HM79-12 | Dilution: 1:10
Clone HM79-12 recognizes the mouse CD79b antigen, a 35-40kD Single-pass type I membrane protein also known as B-cell antigen receptor complex-associated protein beta chain (Igβ chain). The heterodimeric CD79 molecule is composed of an α chain (CD79a) and a β chain (CD79b) and is associated with surface immunoglobulins to form the B cell receptor. The CD79a/CD79b heterodimer facilitates the differentiation of pre-B cells from pro-B cells, surface expression of surface Ig, signal transduction following antigen recognition and endocytosis of recognized antigens. Crosslinking of CD79b in vitro by monoclonal antibodies activates pre-B cells but blocks terminal differentiation of all plasma cell isotypes. It was shown that a combination of CD79α and CD79β monoclonal antibodies can effectively deplete B cells from peripheral blood, spleen, bone marrow, and lymph nodes in mice.

Alternative Names

B29, Igbeta, Igb

Technical specifications

  • Antigen: CD79b
  • Clone: HM79-12
  • Isotype: hamster IgG
  • Alternative names of antigen: B29, Igbeta, Igb
  • Entrez Gene ID: 15985
  • Molecular mass of antigen [kDa]: 23
  • Distribution of antigen: B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected References

    1. Li, Y. et al. (2008) B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL/lpr mice. J. Immunol. 181(5): 2961-2972
    2. Lin, J. and Justement, L. B. (1992) The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases. J. Immunol. 149: 1548-1555
    3. O'Neill, S. K. et al. (2011) Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy. Immunity 35(5): 746-756
Product options: 10

Product information

Size
Order no.
Price

CD79b-PE, mouse

  • HM79-12
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-105-892
-

CD79b-PE, mouse

  • HM79-12
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-105-833
-

CD79b-APC, mouse

  • HM79-12
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-105-893
-

CD79b-APC, mouse

  • HM79-12
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-105-834
-

CD79b-PE-Vio770, mouse

  • HM79-12
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-105-894
-

CD79b-PE-Vio770, mouse

  • HM79-12
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-105-835
-

CD79b-APC-Vio770, mouse

  • HM79-12
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-105-895
-

CD79b-APC-Vio770, mouse

  • HM79-12
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-105-836
-

CD79b-Biotin, mouse

  • HM79-12
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-105-891
-

CD79b-Biotin, mouse

  • HM79-12
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-105-832
-