CD79a antibodies, human

CD79a antibodies, human

Clone: HM47 | Dilution: 1:10
The monoclonal antibody HM47 reacts with the cytoplamic domain of CD79a, which is also known as mb-1 and Ig α. Along with CD79b (Ig β), CD79a is associated with surface Ig (sIg) to form the B cell antigen receptor complex. CD79a is a 47 kDa glycoprotein and comprises a single extracellular immunoglobulin domain, a transmembrane domain, and an signaling intracellular domain with immunoreceptor tyrosine-based activation motif (ITAM). CD79a/CD79b heterodimer facilitates differentiation of pre-B cells from pro-B cells, surface expression of sIg, signal transduction following antigen recognition and enodocytosis of recognised antigens. Surface expression of CD79a dimishes in plasma cells, where it is mainly found as an intracellular molecule. CD79 is considered a B cell–specific marker and is often used to identify the B cell lineage of acute lymphoblastic leukemia. Recent reports however suggest expression of CD79a in T cell acute lymphoblastic leukemia. Individuals lacking CD79a have low/absent circulating pre-B cells and serum antibodies due to a block in B cell development.

Alternative Names

Igα, MB1

Technical specifications

  • Antigen: CD79a
  • Clone: HM47
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: Igα, MB1
  • Entrez Gene ID: 973
  • Molecular mass of antigen [kDa]: 22
  • Cross-reactivity:
    chimpanzee (
    Pan troglodytes
    )
    ,
    olive baboon (
    Papio anubis
    )
    , mouse
  • Distribution of antigen: B cells, lymphocytes, plasma cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, APC-Vio770
Product options: 8

Product information

Size
Order no.
Price

CD79a-PE, human

  • HM47
  • 1:10
  • For research use only
for 30
tests
(1)
130-098-658
-

CD79a-PE, human

  • HM47
  • 1:10
  • For research use only
for 100
tests
(1)
130-098-657
-

CD79a-APC, human

  • HM47
  • 1:10
  • For research use only
for 30
tests
(1)
130-098-693
-

CD79a-APC, human

  • HM47
  • 1:10
  • For research use only
for 100
tests
(1)
130-098-665
-

CD79a-PE-Vio770, human

  • HM47
  • 1:10
  • For research use only
for 30
tests
(1)
130-104-226
-

CD79a-PE-Vio770, human

  • HM47
  • 1:10
  • For research use only
for 100
tests
(1)
130-104-193
-

CD79a-APC-Vio770, human

  • HM47
  • 1:10
  • For research use only
for 30
tests
(1)
130-104-238
-

CD79a-APC-Vio770, human

  • HM47
  • 1:10
  • For research use only
for 100
tests
(1)
130-104-205
-

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