CD68 antibodies, human

CD68 antibodies, human

Clone: REA886 | Dilution: 1:50
Clone REA886 recognizes the human CD68 antigen, a 110 kDa type I transmembrane glycoprotein classified as a lysosomal/endosomal–associated membrane glycoprotein (LAMP) family member. CD68 is highly expressed by human monocytes and tissue macrophages but also found in subpopulations of B cells, fibroblasts, endothelial cells, and other cells. It is found predominantly in late endosomal and lysosomal compartments, with a modest level of cell surface expression. CD68 is suggested to be involved in phagocytic activities of tissue macrophages, in intracellular lysosomal metabolism, and extracellular cell-cell and cell-pathogen interactions.
Additional information: Clone REA886 displays negligible binding to Fc receptors.

Alternative Names

gp110, Lamp4, SCARD1, macrosialin

Technical specifications

  • Antigen: CD68
  • Clone: REA886
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: gp110, Lamp4, SCARD1, macrosialin
  • Entrez Gene ID: 968
  • Molecular mass of antigen [kDa]: 35
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: monocytes, macrophages, B cells, fibroblasts, endothelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, PE-Vio770, APC-Vio770
  • Selected References

    1. Saito, N. et al. (1991) Ultrastructural localization of the CD68 macrophage-associated antigen in human blood neutrophils and monocytes. Am. J. Pathol. 139: 1053-1059
    2. Holness, C. L. and Simmons, D. L. (1993) Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. Blood 81: 1607-1613
    3. Holness, C. L. et al. (1993) Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family. J. Biol. Chem. 268: 9661-9666
    4. Kurushima, H. et al. (2000) Surface expression and rapid internalization of macrosialin (mouse CD68) on elicited mouse peritoneal macrophages. J. Leukoc. Biol. 67: 104-108
    5. Gottfried, L. A. et al. (2008) Expression of CD68 in non-myeloid cell types. Scand. J. Immunol. 67: 453-463

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