CD64 antibodies, mouse

CD64 antibodies, mouse

Clone: REA286 | Dilution: 1:10
Clone REA286 recognizes the CD64 antigen, a 72 kDa integral membrane glycoprotein also known as high affinity immunoglobulin gamma Fc receptor I (FcγRI). Structurally CD64 is composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 is constitutively expressed on macrophages, monocytes, dendritic cells, and mast cells. Treatment with cytokines like IFN-γ and G-CSF induces CD64 upregulation. CD64 binds monomeric IgG-type antibodies with high affinity and mediates endocytosis, phagocytosis, antibody-dependent cellular toxicity, cytokine release, and superoxide generation.
Additional information: Clone REA286 displays negligible binding to Fc receptors.

Alternative Names

FCGR1, FcgammaRI, IGGHAFC, FcR I, FcγRI

Technical specifications

  • Antigen: CD64
  • Clone: REA286
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: FCGR1, FcgammaRI, IGGHAFC, FcR I, FcγRI
  • Entrez Gene ID: 14129
  • Molecular mass of antigen [kDa]: 42
  • Distribution of antigen: dendritic cells, macrophages, monocytes, mast cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
Product options: 2

Product information

Size
Order no.
Price

CD64-APC, mouse

  • REA286
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-103-879
-

CD64-APC, mouse

  • REA286
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-103-809
-

Related products

3 products available