CD62P antibodies, mouse

CD62P antibodies, mouse

Clone: REA344 | Dilution: 1:10
Clone REA344 recognizes the mouse CD62P antigen, a 140 kD Single-pass type I membrane protein also known as P-selectin or Platelet activation dependent granule-external membrane protein (PADGEM). CD62P is expressed by vascular endothelial cells and platelets. The protein is stored preformed in the Weibel-Palade bodies of endothelial cells and in the α-granules of platelets. Upon stimulation of these cells with a variety of agonists such as thrombin or histamine, P-selectin is rapidly translocated to the cell surface, where it mediates leukocyte-platelet and leukocyte-vascular endothelial cell adhesion. The interaction of P-selectin with mature leukocytes is in part responsible for mediating leukocyte rolling on vascular cells - an early event in leukocyte recruitment at sites of inflammation. In addition to its role as a receptor for mature neutrophils and monocytes, P-selectin also functions as a cell adhesion molecule for leukocyte precursor cells in the bone marrow, including both lineage-restricted clonogenic progenitors and hierarchically more primitive progenitor cells.
Additional information: Clone REA344 displays negligible binding to Fc receptors.

Alternative Names

SELP, GMP-140, GRMP, LECAM3, PADGEM, P-selectin

Technical specifications

  • Antigen: CD62P
  • Clone: REA344
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: SELP, GMP-140, GRMP, LECAM3, PADGEM, P-selectin
  • Entrez Gene ID: 20344
  • Molecular mass of antigen [kDa]: 79
  • Distribution of antigen: endothelial cells, platelets
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, APC-Vio770, Biotin
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