CD62E antibodies, mouse

CD62E antibodies, mouse

Clone: REA369 | Dilution: 1:50
Clone REA369 recognizes the mouse CD62E antigen, a single-pass type I membrane glycoprotein also known as E-selectin. CD62E is expressed on endothelial cells and plays a critical role in the recruitment of the appropriate blood cell into specific local sites. It mediates the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with P-selectin glycoprotein ligand 1, which promotes slow rolling and adhesion. CD62E is transcriptionally induced in response to inflammatory cytokines, such as IL-1β and TNFα. It has an important role during hematopoietic stem/progenitor cell trafficking to the bone marrow, and for the maintenance of their quiescent phenotype
in vivo
. Because selectins are also constitutively expressed in the endothelium of certain tissues such as bone marrow even in the absence of inflammatory stimulation, there has been a growing appreciation that these receptors may be important for tissue homeostasis. Elevated cellular levels of CD62E have been documented in various diseases associated with a pro-inflammatory condition, including diabetes, atherosclerosis, rheumatoid arthritis, and cancer. Conversely, therapeutic strategies, which reduce vascular injury, result in significant down-regulation of CD62E gene expression.
Additional information: Clone REA369 displays negligible binding to Fc receptors.

Alternative Names

SELE, E-selectin, ELAM-1, Elam, LECAM2

Technical specifications

  • Antigen: CD62E
  • Clone: REA369
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: SELE, E-selectin, ELAM-1, Elam, LECAM2
  • Entrez Gene ID: 20339
  • Molecular mass of antigen [kDa]: 65
  • Distribution of antigen: endothelial cells, bone marrow, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
Product options: 1

Product information

Size
Order no.
Price

CD62E-PE, mouse

  • REA369
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-119-654
-

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