CD6 antibodies, mouse

CD6 antibodies, mouse

Clone: REA311 | Dilution: 1:10
Clone REA311 recognizes the murine CD6 antigen, a Single-pass type I membrane protein which is expressed on most CD4+CD8+ double-positive, CD4+ or CD8+ single-positive thymocytes, and at highest levels on mature CD3+ thymocytes. In marked contrast to human CD6, mouse CD6 has a long cytoplasmic tail that is not closely related to other proteins. CD6 functions as an adhesion molecule as well as costimulatory molecule for TCR-mediated T cell activation. In thymocytes that express heterogeneous TCR, CD6 increases occur as double-positive thymocytes are selected to a single-positive stage. In contrast, in thymocytes from TCR transgenic mice, CD6 is barely increased following selection, suggesting that as functional avidity increases, requirements for CD6-dependent co-stimulation decrease. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection.
Additional information: Clone REA311 displays negligible binding to Fc receptors.

Alternative Names

T-cell differentiation antigen CD6

Technical specifications

  • Antigen: CD6
  • Clone: REA311
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: T-cell differentiation antigen CD6
  • Entrez Gene ID: 12511
  • Molecular mass of antigen [kDa]: 71
  • Distribution of antigen: thymocytes, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
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