CD54 (ICAM-1) antibodies, mouse

CD54 (ICAM-1) antibodies, mouse

Clone: REA171 | Dilution: 1:10
Clone REA171 recognizes the murine CD54 antigen, a type I transmembrane glycoprotein also known as intercellular adhesion molecule 1 (ICAM-1). CD54 is continuously present in low concentrations in the membranes of monocytes/macrophages, lymphocytes, activated endothelial cells, granulocytes, and dendritic cells. Its expression is regulated by inflammatory cytokines and can be induced by interleukin-1 and tumor necrosis factor. CD54 is a ligand for LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). When activated, leukocytes bind to endothelial cells via CD54/LFA-1 and then transmigrate into tissues.
Additional information: Clone REA171 displays negligible binding to Fc receptors.

Alternative Names

ICAM-1, Ly-47, MALA-2

Technical specifications

  • Antigen: CD54 (ICAM-1)
  • Clone: REA171
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: ICAM-1, Ly-47, MALA-2
  • Entrez Gene ID: 15894
  • Molecular mass of antigen [kDa]: 56
  • Distribution of antigen: granulocytes, lymphocytes, macrophages, monocytes, endothelial cells, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, VioBright 515, Biotin
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