CD54 (ICAM-1) antibodies, mouse

CD54 (ICAM-1) antibodies, mouse

Clone: REA171 | Dilution: 1:10
Clone REA171 recognizes the murine CD54 antigen, a type I transmembrane glycoprotein also known as intercellular adhesion molecule 1 (ICAM-1). CD54 is continuously present in low concentrations in the membranes of monocytes/macrophages, lymphocytes, activated endothelial cells, granulocytes, and dendritic cells. Its expression is regulated by inflammatory cytokines and can be induced by interleukin-1 and tumor necrosis factor. CD54 is a ligand for LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). When activated, leukocytes bind to endothelial cells via CD54/LFA-1 and then transmigrate into tissues.
Additional information: Clone REA171 displays negligible binding to Fc receptors.

Alternative Names

ICAM-1, Ly-47, MALA-2

Technical specifications

  • Antigen: CD54 (ICAM-1)
  • Clone: REA171
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: ICAM-1, Ly-47, MALA-2
  • Entrez Gene ID: 15894
  • Molecular mass of antigen [kDa]: 56
  • Distribution of antigen: granulocytes, lymphocytes, macrophages, monocytes, endothelial cells, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, VioBright 515, Biotin
  • Selected References

    1. Fine, J. S. et al. (1991) The role of LFA-1/ICAM-1 interactions during murine T lymphocyte development. J. Immunol. 147(9): 2852-2859
    2. Siu, G. et al. (1989) Isolation of the murine intercellular adhesion molecule 1 (ICAM-1) gene. ICAM-1 enhances antigen-specific T cell activation. J. Immunol. 143(11): 3813-3820
    3. Driessens, M. H. et al. (1996) Inhibition and stimulation of LFA-1 and Mac-1 functions by antibodies against murine CD18. Evidence that the LFA-1 binding sites for ICAM-1, -2, and -3 are distinct. J. Leukoc. Biol. 60(6): 758-765
Product options: 14

Product information

Size
Order no.
Price

CD54 (ICAM-1)-FITC, mouse

  • REA171
  • 1:10
  • For research use only
9 µg in 300 µL
130-104-246
-

CD54 (ICAM-1)-FITC, mouse

  • REA171
  • 1:10
  • For research use only
30 µg in 1 mL
130-104-214
-

CD54 (ICAM-1)-PE, mouse

  • REA171
  • 1:10
  • For research use only
9 µg in 300 µL
130-104-247
-

CD54 (ICAM-1)-PE, mouse

  • REA171
  • 1:10
  • For research use only
30 µg in 1 mL
130-104-215
-

CD54 (ICAM-1)-APC, mouse

  • REA171
  • 1:10
  • For research use only
9 µg in 300 µL
130-104-248
-

CD54 (ICAM-1)-APC, mouse

  • REA171
  • 1:10
  • For research use only
30 µg in 1 mL
130-104-216
-

CD54 (ICAM-1)-PE-Vio770, mouse

  • REA171
  • 1:10
  • For research use only
9 µg in 300 µL
130-104-249
-

CD54 (ICAM-1)-PE-Vio770, mouse

  • REA171
  • 1:10
  • For research use only
30 µg in 1 mL
130-104-217
-

CD54 (ICAM-1)-APC-Vio770, mouse

  • REA171
  • 1:10
  • For research use only
9 µg in 300 µL
130-104-250
-

CD54 (ICAM-1)-APC-Vio770, mouse

  • REA171
  • 1:10
  • For research use only
30 µg in 1 mL
130-104-218
-

CD54 (ICAM-1)-VioBright 515, mouse

  • REA171
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-109-048
-

CD54 (ICAM-1)-VioBright 515, mouse

  • REA171
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-108-992
-

CD54 (ICAM-1)-Biotin, mouse

  • REA171
  • 1:10
  • For research use only
9 µg in 300 µL
130-104-245
-

CD54 (ICAM-1)-Biotin, mouse

  • REA171
  • 1:10
  • For research use only
30 µg in 1 mL
130-104-213
-