CD49f antibodies, human and mouse

CD49f antibodies, human and mouse

Clone: GoH3 | Dilution: 1:11
Clone GoH3 reacts with CD49f, a 120 kDa transmembrane glycoprotein also known as α6 integrin. Integrins are integral cell-surface proteins composed of an α chain and a β chain and are involved in cell adhesion as well as cell-surface mediated signaling. CD49f associates with integrin β1 chain (CD29) to form VLA-6 and with integrin β4 chain (CD104) to form the α6 β4 complex, which plays a critical structural role in the hemidesmosome and constitutes a receptor for laminin in epithelial cells. CD49f is furthermore expressed on T cells, monocytes, platelets, endothelial cells, trophoblasts of placenta, and spermatogonial stem cells. Clone GoH3 antibody has been reported to block laminin binding
in vitro
and to block integrin α6 function
in vivo

Alternative Names

ITGA6, α6 integrin, ITGA6B, VLA-6, CD49f, VLA-6α

Technical specifications

  • Antigen: CD49f
  • Clone: GoH3
  • Isotype: rat IgG2aκ
  • Isotype control: Rat IgG2a – isotype control antibodies
  • Alternative names of antigen: ITGA6, α6 integrin, ITGA6B, VLA-6, CD49f, VLA-6α
  • Entrez Gene ID: 3655
  • Molecular mass of antigen [kDa]: 124
  • Cross-reactivity: porcine, dog,
    rhesus monkey (
    Macaca mulatta
    cynomolgus monkey (
    Macaca fascicularis
    olive baboon (
    Papio anubis
    chimpanzee (
    Pan troglodytes
    , capuchin monkey
  • Distribution of antigen: brain, cancer stem cells, epithelial cells, hematopoietic stem cells, kidney, liver, lung, lymphocytes, megakaryocytes, monocytes, ovary, platelets, ES and iPS cells, spleen, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Biotin
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