CD49e antibodies, human

CD49e antibodies, human

Clone: REA686 | Dilution: 1:50
Clone REA686 recognizes the human CD49e antigen, also known as integrin α5 chain. Integrins are cell-surface receptors, expressed as heterodimers essential in various processes mediating intercellular or cellmatrix interaction. Integrin α5 is composed of a heavy and a light chain linked by a disulfide bond. CD49e associates non-covalently with the integrin ß1 (CD29) forming the very late activation antigen-5 (VLA5) complex which is expressed on many cell types including peripheral lymphocytes, monocytes, fibroblasts, and endothelial cells and is a receptor for fibronectin and fibrinogen but functions also as a receptor for laminin and several other extracellular matrix proteins.
Additional information: Clone REA686 displays negligible binding to Fc receptors.

Alternative Names

VLA-5α, α5 integrin, VLA-5, Integrin alpha-5

Technical specifications

  • Antigen: CD49e
  • Clone: REA686
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: VLA-5α, α5 integrin, VLA-5, Integrin alpha-5
  • Entrez Gene ID: 3678
  • Molecular mass of antigen [kDa]: 110
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: lymphocytes, monocytes, fibroblasts, endothelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, Biotin
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