CD49d antibodies, human

CD49d antibodies, human

Clone: REA545 | Dilution: 1:50
Clone REA545 recognizes the human CD49d antigen, which belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD49d, also known as the α4 integrin chain or VLA-4α chain, is a cell adhesion protein that is directly involved in mononuclear leukocyte trafficking. Dimerized with β7 integrin, the resulting α4β7 integrin binds VCAM-1 (CD106), MAdCAM-1, and fibronectin to facilitate the rolling of leukocytes along vascular epithelium. In T cells, on ligation of MAdCAM-1, α4β7 integrin also provides costimulation of T cell receptor/CD3–mediated signaling.
CD49d is expressed on most mononuclear leukocytes, both in circulation or in lymphoid or other tissues, as well as on eosinophils and basophils.
Additional information: Clone REA545 displays negligible binding to Fc receptors.

Alternative Names


Technical specifications

  • Antigen: CD49d
  • Clone: REA545
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ITGA4, IA4
  • Entrez Gene ID: 3676
  • Molecular mass of antigen [kDa]: 111
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    cynomolgus monkey (
    Macaca fascicularis
    , baboon,
    chimpanzee (
    Pan troglodytes
    common marmoset (
    Callithrix jacchus
    squirrel monkey (
    Saimiri sciureus
    , horse, cattle (bovine, cow), sheep, dog, cat
  • Distribution of antigen: T cells, leukocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE

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