CD49d antibodies, human

CD49d antibodies, human

Clone: REA545 | Dilution: 1:11
Clone REA545 recognizes the human CD49d antigen, which belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD49d, also known as the α4 integrin chain or VLA-4α chain, is a cell adhesion protein that is directly involved in mononuclear leukocyte trafficking. Dimerized with β7 integrin, the resulting α4β7 integrin binds VCAM-1 (CD106), MAdCAM-1, and fibronectin to facilitate the rolling of leukocytes along vascular epithelium. In T cells, on ligation of MAdCAM-1, α4β7 integrin also provides costimulation of T cell receptor/CD3–mediated signaling.
CD49d is expressed on most mononuclear leukocytes, both in circulation or in lymphoid or other tissues, as well as on eosinophils and basophils.
Additional information: Clone REA545 displays negligible binding to Fc receptors.

Alternative Names

ITGA4, IA4

Technical specifications

  • Antigen: CD49d
  • Clone: REA545
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ITGA4, IA4
  • Entrez Gene ID: 3676
  • Molecular mass of antigen [kDa]: 111
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    , baboon,
    chimpanzee (
    Pan troglodytes
    )
    ,
    common marmoset (
    Callithrix jacchus
    )
    ,
    squirrel monkey (
    Saimiri sciureus
    )
    , horse, cattle (bovine, cow), sheep, dog, cat
  • Distribution of antigen: T cells, leukocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin

Related products

3 products available
Product options: 6

Product information

Size
Order no.
Price

CD49d-APC, human

  • REA545
  • 1:11
  • For research use only
for 30
tests
(1)
130-108-258
-

CD49d-APC, human

  • REA545
  • 1:11
  • For research use only
for 100
tests
(1)
130-108-231
-

CD49d-PE-Vio770, human

  • REA545
  • 1:11
  • For research use only
for 30
tests
(1)
130-108-259
-

CD49d-PE-Vio770, human

  • REA545
  • 1:11
  • For research use only
for 100
tests
(1)
130-108-232
-

CD49d-Biotin, human

  • REA545
  • 1:11
  • For research use only
for 30
tests
(1)
130-108-256
-

CD49d-Biotin, human

  • REA545
  • 1:11
  • For research use only
for 100
tests
(1)
130-108-229
-