CD49d antibodies, human

CD49d antibodies, human

Clone: MZ18-24A9 | Dilution: 1:11
CD49d, also known as the α4 integrin chain or VLA-4α chain, is a 150 kDa cell adhesion protein that is directly involved in mononuclear leukocyte trafficking. Dimerized with β7 integrin, the resulting α4β7 integrin binds VCAM-1 (CD106), MAdCAM-1, and fibronectin to facilitate the rolling of leukocytes along vascular epithelium. In T cells, on ligation of MAdCAM-1, α4β7 integrin also provides costimulation of T cell receptor/CD3–mediated signaling.
CD49d is expressed on most mononuclear leukocytes, both in circulation or in lymphoid or other tissues, as well as on eosinophils and basophils.

Alternative Names

ITGA4, IA4, VLA-4α


The antibody has been tested to cross-react with
  • Rhesus monkey ( Macaca mulatta )
  • Cynomolgus monkey ( Macaca fascicularis )

Technical specifications

  • Antigen: CD49d
  • Clone: MZ18-24A9
  • Isotype: mouse IgG2bκ
  • Isotype control: Mouse IgG2b – isotype control antibodies
  • Alternative names of antigen: ITGA4, IA4, VLA-4α
  • Entrez Gene ID: 3676
  • Molecular mass of antigen [kDa]: 111
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    cynomolgus monkey (
    Macaca fascicularis
  • Distribution of antigen: B cells, basophils, cardiac muscle, dendritic cells, eosinophils, Langerhans cells, lymphocytes, macrophages, mast cells, monocytes, myeloid cells, NK cells, placenta, red blood cells, skeletal muscle, smooth muscle, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, Biotin, pure
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