CD49a antibodies, mouse and rat

CD49a antibodies, mouse and rat

Clone: REA493 | Dilution: 1:10
Clone REA493 recognizes the mouse and rat CD49a antigen, a 180 kDa single-pass type I membrane protein also known as integrin α1 (Itga1). CD49a binds to CD29 (integrin β1) to form the heterodimeric integrin very late antigen 1 (VLA-1), which has been found to be widely expressed on various cell types, including mesenchymal cells, epithelial cells, macrophages, NKT cells, and T cells. VLA-1 is a receptor for laminin and collagen and interacts, via the I-domain of the extracellular domain of the CD49a subunit, with collagen molecules in the extracellular matrix. CD49a expression parallels high levels of IFN-γ production in effector T cells, and CD49a has been intensively studied for its role in mediating T-cell accumulation, apoptosis, and retention within pathological tissues in immune-mediated inflammation.
Additional information: Clone REA493 displays negligible binding to Fc receptors.

Alternative Names

Itga1, VLA-1

Technical specifications

  • Antigen: CD49a
  • Clone: REA493
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Itga1, VLA-1
  • Entrez Gene ID: 25118, 109700
  • Molecular mass of antigen [kDa]: 128
  • Distribution of antigen: macrophages, T cells, epithelial cells, NKT cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
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