CD46 antibodies, human

CD46 antibodies, human

Clone: REA312 | Dilution: 1:11
Clone REA312 recognizes the human CD46 antigen, a type I transmembrane glycoprotein, which is also known as the membrane cofactor protein (MCP). At least fourteen different transcript variants encoding different isoforms have been found for CD46. It is expressed by a broad range of tissues including leukocytes, platelets, epithelial cells, and fibroblasts, but not by erythrocytes. CD46 acts as a co-factor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It is involved in the fusion of the spermatozoa with the oocyte during fertilization. Additionally, CD46 functions as a receptor for measles virus, human herpesvirus, and human adenovirus. It is a potent costimulator for the induction of interferon-γ secreting effector T helper type 1 cells and their subsequent switch into interleukin 10 producing regulatory T cells.
Additional information: Clone REA312 displays negligible binding to Fc receptors.

Alternative Names

Membrane cofactor protein (MCP), AHUS2, MCP, MIC10, TLX, TRA2.10

Technical specifications

  • Antigen: CD46
  • Clone: REA312
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Membrane cofactor protein (MCP), AHUS2, MCP, MIC10, TLX, TRA2.10
  • Entrez Gene ID: 4179
  • Molecular mass of antigen [kDa]: 40
  • Distribution of antigen: leukocytes, platelets, epithelial cells, fibroblasts
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, Biotin
  • Selected References

    1. Le Friec, G. et al. (2012) The CD46-Jagged1 interaction is critical for human Tʜ1 immunity. Nat. Immunol. 13(12): 1213-1221
    2. Dörig, R. E. et al. (1993) The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell 75(2): 295-305
    3. Purcell, D. F. et al. (1991) Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation. Immunogenetics 33(5-6): 335-344
Product options: 14
130-104-556

CD46-FITC, human

for 30
tests
(1)
-
130-104-507

CD46-FITC, human

for 100
tests
(1)
-
130-104-557

CD46-PE, human

for 30
tests
(1)
-
130-104-508

CD46-PE, human

for 100
tests
(1)
-
130-104-558

CD46-APC, human

for 30
tests
(1)
-
130-104-509

CD46-APC, human

for 100
tests
(1)
-
130-106-507

CD46-VioBlue, human

for 30
tests
(1)
-
130-106-458

CD46-VioBlue, human

for 100
tests
(1)
-
130-104-559

CD46-PE-Vio770, human

for 30
tests
(1)
-
130-104-510

CD46-PE-Vio770, human

for 100
tests
(1)
-
130-104-560

CD46-APC-Vio770, human

for 30
tests
(1)
-
130-104-511

CD46-APC-Vio770, human

for 100
tests
(1)
-
130-105-585

CD46-Biotin, human

for 30
tests
(1)
-
130-105-533

CD46-Biotin, human

for 100
tests
(1)
-